I could run Deskpro from my VM image fine until I set a static IP. Now when I go to the IP in my browser, I just see a blank window with the Deskpro favicon.
This can happen if the helpdesk URL setting in Setup > Settings has not been updated.
Add /admin/ to the end of the IP address in your browser and press Enter. You will be able to see the admin interface.
Go to Setup > Settings and edit the Helpdesk URL to use the new IP address.